What to Expect

What to expect with Nutropin AQ® [somatropin (rDNA origin) injection]

It’s normal to feel nervous about starting something new. When you start Nutropin therapy, a nurse will teach you step by step how to inject Nutropin. The NuSpin device will help you get your full dose in 3 simple steps. It is easy to learn, and easy to use. A nurse trainer will be there to help every step of the way.

Taking Nutropin

Nutropin is given as an injection. It is injected into the fatty layer under the skin. Your injection trainer, doctor, and nurse can all show you the right way to take your Nutropin treatment.

Getting the most out of your therapy

It’s best if you take Nutropin at the same time every day. It is usually given in the evening or at a time that is recommended by your health care provider.

If you’re giving an injection to your child, it may be helpful to get him or her involved right from the start. Let your child help to put a routine in place. Having some control may help him or her feel better. 

They may assist with:

  • Helping to get medicine from the refrigerator
  • Opening the alcohol wipes
  • Setting up the supplies

If possible, follow injections with an activity your child enjoys, such as reading together.

Whether you’re giving or getting treatment, remember: Missing injections may affect your response to therapy. Talk to your doctor about missing injections. Don’t try to make up for missed injections by “doubling up” on your dose. Staying on a routine, or setting a cell phone alarm to remind you to take your Nutropin, may help you stay on course. Ask your healthcare provider what to do if you miss a dose.

Nutropin should be taken until your doctor tells you that you don’t need to take it any more. 

Your doctor is your first source of information. Discuss the potential benefits and risks of GH therapy with your doctor so you are familiar with possible side effects. Be sure to talk about any medications you or your child may be taking.

When can I expect to see results from my Nutropin therapy?

It may be a few months before you see any results from your Nutropin therapy. The changes may be so gradual at first that you don’t even notice. If you take it every day and don’t miss doses, you may improve the likelihood of positive results. Individual results may vary.

Common side effects associated with Nutropin therapy

Nutropin may cause some side effects. These may include:

  • Discomfort, soreness, or redness where Nutropin is injected
  • Swelling or joint pain
  • Carpal tunnel syndrome

In the first days and weeks of treatment, some adults and a very few children may have swelling of the hands and feet (edema). Pain and swelling of your joints may also occur. If you have these side effects, let your doctor know right away. Most likely he or she has already talked with you about these side effects and explained that they won’t last.

Always talk with your doctor about any medicine you take. Also be sure to read the Nutropin Prescribing Information. 

Nutropin Prescribing Information - Download PDF (295 KB)

Who is Nutropin Therapy For?

Nutropin AQ [somatropin (rDNA origin) injection] is human growth hormone that is available by prescription only.

Doctors prescribe Nutropin therapy for children and teenagers who are short or growing slowly because they:

  • Do not make enough growth hormone on their own
  • Have idiopathic short stature, which means they are shorter than 98.8% of other children of the same age and sex; are growing at a rate not likely to allow them to reach normal adult height; and no other cause of short stature can be found
  • Have Turner syndrome
  • Have chronic kidney disease (CKD) up to the time of kidney transplant

Doctors prescribe Nutropin therapy for adults who have growth hormone deficiency that began either in:

  • Adulthood as a result of pituitary disease, diseases of the hypothalamus, surgery, radiation therapy, or trauma; or
  • Childhood. Patients treated for growth hormone deficiency in childhood, whose bones have stopped growing, should be reevaluated to see if they need to continue with growth hormone therapy

Your doctor will test to see if growth hormone is right for you

Important Safety Information

Nutropin therapy and your safety:

Please read this important safety information carefully. Then, if you have any questions, talk with your doctor.

Nutropin Therapy is Not For:

  • Patients having serious complications after undergoing open heart surgery, abdominal surgery, serious injuries involving many body systems, or life-threatening breathing problems. Deaths have been reported in such cases
  • Children who have Prader-Willi syndrome (PWS) and are very overweight or have a history of severe breathing problems. Deaths have been reported in children with PWS who are very overweight, have a history of blocked upper airways, sleep apnea (pauses in breathing during sleeping), or other severe breathing problems
  • Patients who have active cancer. Because growth hormone deficiency can be an early sign of some tumors in the brain or pituitary gland, the presence of these types of tumors should be ruled out by your doctor before you start Nutropin therapy
  • Adults or children with certain types of eye disease caused by diabetes
  • Children and teenagers whose bones have finished growing
  • Patients who are allergic to somatropin, the active ingredient in Nutropin therapy. Reactions at the injection site are the most common allergic reactions

What should you tell your doctor before starting Nutropin therapy?

  • If you take cyclosporine, hormone replacement therapy, insulin or other diabetes medications, drugs containing steroids, or drugs for seizures. These medications may need to be adjusted during Nutropin therapy
  • If you have preexisting tumors or growth hormone deficiency caused by abnormal tissue in the brain. If so, you should be watched closely for the worsening or return of this condition. If you had cancer as a child, an increased risk of a new tumor, particularly certain brain tumors, has been reported in patients taking Nutropin therapy
  • If you have diabetes, risk factors for diabetes, or impaired glucose tolerance. If so, your doctor should monitor your blood sugar closely during Nutropin therapy. New cases of type 2 diabetes have been reported in patients taking Nutropin therapy
  • If you have hypopituitarism (an inability of the pituitary gland to produce sufficient hormones) and are on standard hormone replacement therapy. In that case, your doctor should monitor your hormone replacement therapy closely while you are taking Nutropin therapy
  • If you are pregnant, nursing, or plan to become pregnant. It is not known whether Nutropin is excreted in human milk. Nutropin therapy should be used during pregnancy only when clearly needed

While taking Nutropin, contact your doctor immediately if you experience:

  • Changes in vision, a bad headache, or nausea with or without vomiting. This may be a sign of increased pressure in the brain
  • A limp or have hip or knee pain
    • A fracture in the ball of the hip joint can occur in children who have endocrine problems and in children who have rapid growth
    • Children with growth failure due to CKD should be examined periodically for evidence of loss of bone minerals. Hip X-rays should be taken before starting Nutropin therapy in these children
  • Progression of scoliosis (curvature of the spine) that can occur in children who have rapid growth. Nutropin therapy has not been shown to increase the occurrence of this condition
  • Any allergic reaction you experience to the injection of Nutropin therapy
  • Abdominal pain. Cases of pancreatitis (inflammation of the pancreas) have been reported rarely in children and adults receiving Nutropin therapy

Other important information about Nutropin:

  • Adults may retain water during Nutropin therapy. This may be brief but may increase with higher doses of Nutropin therapy
  • Patients should have their thyroid function tested periodically during Nutropin therapy. Thyroid hormone treatment may need to be started or adjusted
  • Patients should be sure to inject Nutropin at a different recommended place on their body each time to avoid tissue breakdown. A doctor or nurse should provide injection training and supervise the first injection
  • The use of Nutropin therapy has not been studied in patients over 65 years of age. Elderly patients may be more sensitive to Nutropin therapy and may experience more side effects
  • Patients with Turner syndrome should be monitored closely by a doctor for ear infections and cardiovascular problems during Nutropin therapy
  • Nutropin therapy may affect the body's ability to process two hormones, cortisol and cortisone, which can lead to a condition called hypoadrenalism (underactivity of the adrenal gland). In that case, glucocorticoid replacement therapy may need to be prescribed

What are common possible side effects of Nutropin therapy?

Common side effects reported in adults and children taking Nutropin therapy include injection site reactions. Additional common side effects in adults include swelling, joint pain, and carpal tunnel syndrome.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

How should you store Nutropin?

Nutropin must be kept refrigerated (36° to 46°F [2° to 8°C]). Do not freeze. Cartridges and NuSpin pens must be used within 28 days of initial use. Throw away any unused Nutropin after 28 days of initial use. Before giving an injection, check the manufacturer's expiration date on the cartridge or pen. Do not use if it has expired. Do not inject medication if the solution is cloudy.

Your healthcare team is your first source of information about your therapy.

Please see the full Prescribing Information for additional important safety information.

The content available from this website is for informational purposes only. Individual results may vary.

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